Applications
One platform for complex biological materials.
Islets are our lead program. Each other application below is labeled with its current stage of development.
Pancreatic islets
Islet transplantation is an approved therapy for people with severe type 1 diabetes, but islets must be used fresh. Few patients receive them, often from a single donor and with little time for testing.
CryoMesh is designed to let islets be pooled across donors, fully tested, matched, and distributed, and to let developers of stem cell-derived islets store production batches in patient doses.
- Demonstrated with human islets and human stem cell-derived islets, as well as porcine and mouse islets; non-human primate islets in unpublished studies.
- 93% viability and recovery after vitrification and rewarming (preprint).
- Designed to support pooling across donors, extended quality testing, HLA matching, global distribution, and batch storage of stem cell-derived islets.
Precision-cut tissue slices
Precision-cut tissue slices retain the structure and cell diversity of living tissue, which makes them valuable for drug testing and disease research. Their short usable life limits how widely they can be shared and reused.
In a peer-reviewed study, rat precision-cut liver slices vitrified on a polymer cryomesh kept their viability, morphology, function, and drug toxicity response over 3 days of culture, comparable to untreated controls (Ramesh et al., Bioengineering & Translational Medicine, 2025).
Organoids and spheroids
Organoids and cell spheroids are increasingly used in regenerative medicine, disease modeling, and drug safety testing. Like islets, they are multicellular clusters that conventional freezing tends to damage.
Potential applications include neural, hepatic, and cardiac organoids.
Other cell clusters
The same principles extend to other small, multicellular systems. In academic research, cryomesh approaches have been used to cryopreserve Drosophila embryos (Zhan et al., Nature Communications, 2021) and, with a conduction-dominated design, to vitrify coral larvae and Drosophila and zebrafish embryos (Guo et al., Advanced Science, 2024).
Collaborate
Partner with us
We work with developers of islet and cell-based therapies to evaluate CryoMesh in their programs. Major pharmaceutical companies are evaluating CryoMesh.